Do hollows, puffiness, or dark circles make your eyes appear worn out? You're not alone. Regardless of age or gender, under-eye issues affect a lot of people.
The good news? Mesotherapy under the eyes can be the non-invasive solution you require.
However, how does mesotherapy operate and what is it? Can it take the place of blepharoplasty without surgery? To find out, continue reading.
What is Mesotherapy Under the Eyes
Mesotherapy under the eyes involves the injection of a combination of vitamins, amino acids, and hyaluronic acid into the skin. It is a minimally invasive procedure that decreases pigmentation, increases collagen, and promotes moisture.
Historically, mesotherapy originated in France. The procedure has been utilized for a variety of medical and cosmetic goals. But, can you treat mesotherapy under the eyes at home? While you can DIY mesotherapy in other areas, you may need a professional to handle it under the eyes.
One of the main objectives for under-eye issues is to revitalize the sensitive skin, giving it a youthful, renewed appearance. Mesotherapy enhances skin repair and regeneration by delivering vital nutrients straight into the skin layers.
Mesotherapy is particularly helpful if you wish to stay away from more invasive procedures like fillers or nonsurgical blepharoplasty.
How Does It Operate?

A specially formulated mixture of active substances is administered directly to the under-eye region as part of mesotherapy. By increasing circulation, hydrating the skin, and stimulating the creation of collagen, these micro-injections make the area beneath the eyes appear firmer and more radiant.
According to the Indian Journal of Dermatology, Venereology, and Leprology, the procedure is quick, with minimal discomfort and little to no downtime. Here’s what to anticipate along the process:
Consultation and Evaluation
At first, a specialist evaluates the under-eye issues and chooses the appropriate combination of components. The number of sessions needed and the treatment plan are discussed.
Getting ready
To get rid of oil and debris, the region under the eyes is cleansed. Then, the application of numbing cream follows to reduce discomfort.
Procedure for Injection
Tiny volumes of specially made serums are injected beneath the eyes using microneedles. For the best results, Diaminy crystal multi-injector needles, such as the 3-pin and 4-pin multi-needles, are used for mesotherapy injections under the eyes. These needles ensure accurate and uniform dispersion of the treatment fluid.
In order to target the mesoderm (middle skin layer), the injection depth is meticulously regulated. Plus, the active components injected like vitamins, peptides, and hyaluronic acid enhance collagen synthesis, circulation, and hydration.
Care Following Treatment
For a few hours, the skin can be a little red or puffy. Therefore, for a whole day, patients are recommended to abstain from drinking alcohol, intense exercise, and direct sun exposure.
Gradual Improvement
Over several sessions, usually separated by two to four weeks, you will see positive results. The area beneath the eyes will look younger, firmer, and brighter over time.
Patients may have some redness or swelling following each session, but this usually goes away in a few hours. Over time, the texture of the skin gets better, and puffiness or dark circles become less obvious.
Who Makes a Good Candidate?

Mesotherapy under the eyes may help if you have:
● Dark circles brought on by pigmentation problems or inadequate circulation.
● Creases and fine lines that give the under-eye area an aged appearance.
● Under eye hollows that give them a sunken look.
● Male bags under eyes as a result of fluid retention.
● Eyes that appear worn out and in need of a new, renewed appearance.
Non surgical blepharoplasty may be a preferable choice if you're worried about severely sagging skin. However, mesotherapy alone might not produce the desired effects for patients with deep hollows or large under-eye fat deposits. The ideal course of therapy can be decided with the assistance of a certified professional consultation.
Benefits of Under-Eye Mesotherapy
1. Treats Pigmentation and Dark Circles
The skin-brightening substances in mesotherapy injections include Vitamin C, glutathione, and amino acids which enhance your skin tone while reducing hyperpigmentation.
These injections work well for vascular dark circles that stem from poor blood circulation.
2. Plumps and Hydrates the Skin
The mesotherapy procedure saturates under-eye tissue layers with hyaluronic acid therefore creating a smoother youthful appearance.
The procedure enhances tissue volume, helping to plump up loose skin under the eyes.
3. Increases the Production of Collagen
The micro-injections activate fibroblasts to produce more collagen and elastin particles. Mesotherapy's injections create skin tension which gradually makes wrinkles and fine lines less noticeable.
4. Very little downtime

Compared with invasive procedures mesotherapy maintains little or no recovery period. The procedure allows patients to perform normal daily activities minutes after their treatment.
5. Non-Surgical and Safe
Mesotherapy poses less medical risk than both surgical blepharoplasty combined with intense laser treatments. Patients experience no surgical cuts or necessary stitches that result in scars post-procedure.
6. Adaptable Components
The medical professionals creating mesotherapy solutions have the capability to modify these mixtures for distinct medical purposes including anti-aging care, skin brightening, and hydration needs.
Aesthetic physicians adjust the medical formula based on individual skin type needs to achieve the desired outcomes.
7. Results That Appear Natural
The slow treatment approach delivers enhancements that yield realistic, natural-looking results, blending seamlessly with your face's natural characteristics.
Cons of Under-Eye Mesotherapy

1. Needs several sessions
The recommended number of treatments is between three to six sessions that should be performed at intervals of one to two weeks.
Unlike fillers that supply instant volumization, mesotherapy requires multiple sessions before showing its effects.
2. Short-term outcomes (Needs upkeep)
Patients need touch-ups to maintain their results because the treatment effects survive between 6–12 months. Without regular maintenance, dehydration, and dark circles may reoccur.
3. Ineffective for loose skin or severe under-eye bags
The effects of mesotherapy cannot remove fat accumulation underneath the eyes. Sagging skin needs fillers while severe under-eye puffiness requires non surgical blepharoplasty instead of mesotherapy.
4. Minor adverse reactions (bruising & swelling)
The treatment commonly causes light bruises, minor swelling, and red skin patches when performed on individuals with delicate skin.
While the bruising may take a few days to go away, the swelling normally goes away in 24 to 48 hours.
5. A Little uncomfortable during therapy
Multiple tiny injection points are required during the treatment process which periodically causes discomfort and related pain. A numbing cream is administered before treatment to lessen patient discomfort.
6. Needs an experienced professional
Improperly performed mesotherapy treatments can lead to infections, edema, and uneven therapy effects. To ensure safety and effectiveness, patients should select a cosmetic specialist who possesses both knowledge and professional expertise.
What is the Required Number of Sessions?
Patients typically need between three to six treatments conducted every two to four weeks for results to become visible but outcomes differ from one person to another. Additional procedures help maintain the outcomes from your initial procedures.
The number of treatment sessions depends entirely on a person's individual requirements. People may detect significant improvements soon after 1-2 sessions but multiple treatments could be necessary before noticeable changes become apparent.
What to Expect After Treatment
1. The treatment usually causes minimal swelling along with reddened skin that should resolve within a few hours.
2. You may have minimal discomfort as part of the treated area may become sensitive to touch for some patients.
3. Small bruises occasionally form after treatment which disappears within the next few days.
4. The lower eyelid area shows immediate improvement with plumpness and enhanced hydration. However, repeated treatment sessions reveal enhanced results over time.
5. Avoid alcohol, restrict exercise, and limit sun exposure for the entire day following treatment.
6. Use cold compresses to reduce post-therapy edema development.
7. Observe the skin care guidelines. Long-term effects are improved by keeping the skin hydrated and protected from the sun.
Duration of the Outcomes
The results of this approach last between six months to one year. Regular water consumption and consistent sunscreen use helps enhance and maintain the treatment advantages over time.
Mesotherapy treatments deliver skin hydration benefits over a longer period than filler treatments, which provide immediate volume enhancement.
Can Fillers Be Replaced by Mesotherapy?

Mesotherapy may be an excellent substitute for filler if you're wondering how to plump under eyes hollows. It is most effective, though, on mild to moderate hollows. Fillers may still be necessary for deeper hollows to visibly restore volume.
For under-eye rejuvenation, mesotherapy is often considered a gentler alternative to dermal fillers. However, the particular issue being addressed will determine whether it can completely replace fillers.
How Mesotherapy Compares to Fillers
1. Volume Restoration
By promoting the development of collagen and elastin, mesotherapy plumps and moisturizes the area beneath the eyes.
Fillers on the other hand directly add hyaluronic acid or other materials to fill in hollows. While this occurs, fillers instantly increase volume.
Sadly, mesotherapy might not be sufficient to replace lost volume if you have deep under-eye hollows.
2. Skin rejuvenation and hydration
Mesotherapy increases the elasticity, moisture, and texture of the skin. But, fillers have little effect on the quality of the skin and are mostly used to add volume and structure.
Basically, mesotherapy is an excellent choice if you want to gradually and naturally increase the hydration and brightness under your eyes.
3. Timeline for Treatment
Results from mesotherapy under the eyes become apparent over time as it operates gradually over several sessions.
After just one session, fillers provide instant benefits.
Fillers might be a better option if deep hollows need to be corrected quickly.
4. Duration of Outcomes
Results from mesotherapy usually require follow-up treatments after 6 to 12 months. Still, it all depends on your metabolism. Fillers can last anywhere from six to eighteen months.
Frequent mesotherapy sessions may help postpone the need for fillers or extend their effectiveness.
5. Relevance for Various Under-Eye Issues
Mesotherapy under the eyes works perfectly on dehydration, pigmentation, and fine wrinkles. Besides, it may be helpful in mild to moderate under-eye hollows, but it might not significantly increase volume.
When you have deep tear troughs or severe under-eye hollows you will need fillers for a significant repair.
6. Risks and Adverse Reactions
Compared to fillers, mesotherapy is less likely to cause lumpiness or migration. Moreover, inadequate injection of fillers may result in unevenness or problems like the Tyndall effect, which causes a bluish tinge beneath the skin. But, don’t worry—- the National Institute of Health gives a solution on how to manage it.
Mesotherapy improves the firmness and moisture of the skin, giving the area beneath the eyes a smoother appearance. It doesn't, however, offer as much volume as dermal fillers. To get the best outcomes, a combination of the two treatments could be suggested in some circumstances.
How to Fix Under Eye Hollows Without Fillers

To treat under-eye hollows without fillers, try using an eye cream containing hyaluronic acid, obtaining adequate sleep, and maintaining proper hydration.
Facial fat transfer is also another non-invasive procedure that may help restore volume, and cold compresses can lessen puffiness.
Is Mesotherapy Superior to Blepharoplasty Without Surgery?
Although they both address under-eye issues, their methods differ:
● The goals of mesotherapy are pigmentation, circulation, and hydration.
● Non surgical blepharoplasty: Tightens your skin and eliminates extra fat using plasma energy.
So, what are you aiming to achieve? Your goals will determine your decision. If your primary problem is drooping skin, non surgical blepharoplasty may be a better option. Mesotherapy is perfect for brightness and hydration.
Although both therapies are beneficial, their functions are distinct. For better outcomes, some patients decide to combine the two, treating both skin laxity and volume loss.
Key Differences Between Mesotherapy and Non Surgical Blepharoplasty
Feature |
Mesotherapy |
Non-Surgical Blepharoplasty |
Primary Function |
Hydration, collagen boost, pigmentation reduction |
Skin tightening, wrinkle reduction, fat shrinkage |
Best For |
Dark circles, fine lines, mild under-eye hollows |
Loose skin, excess fat, severe wrinkles |
How it Works |
Micro-injections deliver vitamins, amino acids, and hyaluronic acid to rejuvenate skin |
Plasma energy stimulates fibroblasts to tighten skin and reduce excess tissue |
Treatment Time |
15–30 minutes per session |
30–45 minutes per session |
Number of Sessions Required |
3–6 sessions for optimal results |
1–3 sessions, depending on severity |
Results Timeline |
Gradual improvement over several weeks |
Visible results within days, with full effect in 2–3 months |
Longevity of Results |
6–12 months, with maintenance |
1–3 years, depending on skin aging |
Pain Level |
For mild discomfort, numbing cream may be used |
Moderate discomfort, numbing required |
Downtime |
Minimal (mild swelling or redness for a few hours) |
3–7 days of scabbing and mild swelling |
Which Therapy Works Best?
Your goal will determine whether mesotherapy or non surgical blepharoplasty is more effective.
1. Dehydration & Dark Circles
The combination of skin-nourishing substances used in mesotherapy can increase circulation and brighten the area under your eyes, especially if pigmentation, dullness, or a fatigued appearance are your main concerns.
It is particularly effective for those with dark circles caused by dehydration, thinning skin, or impaired blood circulation.
2. Wrinkles and Loose Skin
Non surgical blepharoplasty is more effective if sagging skin or deep creases are your primary problem.
Since plasma energy tightens the skin, it's a better choice for those beginning to show signs of aging.
3. Puffiness and Under-eye bags
Are eye bags permanent? Treatments that use plasma or lasers to tighten the skin and reduce fat deposits are more effective in treating puffy eyes brought on by fat buildup.
Since mesotherapy doesn't break down fat, it cannot work for extreme puffiness. Both can be effective for mild under-eye hollows and fine lines.
4. Fine lines
Fine lines are gradually reduced with mesotherapy under the eyes, which moisturizes the skin and increases collagen.
According to research by the National Library of Medicine, when you undergo non surgical blepharoplasty, the skin is tightened but no moisture is added.
But the finest effects for enhancing your skin's firmness and texture can often come from combining the two treatments.
Is It Possible to Combine the Two Treatments?

Yes! Combining mesotherapy under the eyes with non surgical blepharoplasty is often the most effective approach.
Step 1: To tighten skin and lessen puffiness, get a non surgical blepharoplasty first.
Step 2: To preserve a youthful glow and enhance moisture, continue with mesotherapy.
This method gives the under-eye area firmness and deep skin renewal, resulting in a more youthful appearance.
Conclusion
Mesotherapy under the eyes is a fantastic approach to revitalizing your appearance if you're sick of looking fatigued. This procedure provides a non-invasive way to gradually remove dark circles, puffiness, or hollows, with results that seem natural.
The best result, meanwhile, might come from combining mesotherapy with non surgical blepharoplasty for more serious issues. Always get advice from a trained expert to determine the best course of action for you.
Now, are you looking for excellent outcomes for under eyes? Use Diaminy’s meso needles today!